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在大鼠中,妊娠早期以及受卵巢激素影响时,子宫上皮细胞的基底质膜和致密板都会发生改变。

The basal plasma membrane and lamina densa of uterine epithelial cells are both altered during early pregnancy and by ovarian hormones in the rat.

作者信息

Shion Y L, Murphy C R

机构信息

Department of Anatomy and Histology, University of Sydney, NSW Australia.

出版信息

Eur J Morphol. 1995 Jul;33(3):257-64.

PMID:8534579
Abstract

Changes in the basal plasma membrane and lamina densa of uterine epithelial cells have been studied in the rat during early pregnancy and under the influence of progesterone and oestrogen. Both the basal plasma membrane and lamina densa become increasingly tortuous by day 6 of pregnancy and this condition is found to be predominantly influenced by progesterone. Oestrogen, either alone or in combination with progesterone, has a much lesser effect. The lamina densa increases in thickness by day 6 of pregnancy and again progesterone is found to have the major influence. These alterations are discussed in the context of implantation of the blastocyst and we highlight the differing effect that ovarian hormones have on different regions of the plasma membrane of uterine epithelial cells.

摘要

在大鼠怀孕早期以及在孕酮和雌激素的影响下,对子宫上皮细胞的基底质膜和致密层的变化进行了研究。到怀孕第6天时,基底质膜和致密层都变得越来越曲折,并且发现这种情况主要受孕酮影响。单独使用雌激素或雌激素与孕酮联合使用时,其影响要小得多。到怀孕第6天时,致密层厚度增加,同样发现孕酮起主要作用。在胚泡着床的背景下讨论了这些变化,并且我们强调了卵巢激素对子宫上皮细胞质膜不同区域的不同影响。

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Ovarian hormones regulate expression of the focal adhesion proteins, talin and paxillin, in rat uterine luminal but not glandular epithelial cells.
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