Graff J, Joffe P, Fugleberg S, Jensen L T
Department of Nephrology, Herlev Hospital, Denmark.
Adv Perit Dial. 1995;11:24-7.
Possible relationships between the dialysate-to-plasma creatinine equilibration ratio (D/Pcreatinine 4 hour), duration of peritoneal dialysis treatment, number of peritonitis episodes, and mass appearance rates of three connective tissue markers [carboxyterminal propeptide of type I procollagen (PICP), aminoterminal propeptide of type III procollagen (PIIINP), and carboxyterminal telopeptide of type I collagen (ICTP)] were studied in 19 nondiabetic peritoneal dialysis patients. The absence of correlation between the mass appearance rates of the markers and the duration of dialysis treatment as well as the number of peritonitis episodes supports the concept that peritoneal dialysis does not cause persistent changes in the deposition and degradation rates of collagen. A correlation between the D/Pcreatinine 4 hr and the PICP mass appearance rates was found. Since it is unlikely that transperitoneal transport alone is responsible for the appearance of PICP in dialysate, this might reflect an association between a large peritoneal surface area and the amount of submesothelial connective tissue.
在19例非糖尿病腹膜透析患者中，研究了透析液与血浆肌酐平衡率（D/P肌酐4小时）、腹膜透析治疗时间、腹膜炎发作次数以及三种结缔组织标志物[I型前胶原羧基末端前肽（PICP）、III型前胶原氨基末端前肽（PIIINP）和I型胶原羧基末端端肽（ICTP）]的质量出现率之间的可能关系。标志物的质量出现率与透析治疗时间以及腹膜炎发作次数之间缺乏相关性，这支持了腹膜透析不会导致胶原蛋白沉积和降解率持续变化的观点。发现D/P肌酐4小时与PICP质量出现率之间存在相关性。由于仅经腹膜转运不太可能导致透析液中出现PICP，这可能反映了大的腹膜表面积与间皮下结缔组织量之间的关联。
