Shibata K, Shimamoto Y, Yamada H, Miyahara M, Fukushima N, Yano H
Department of Internal Medicine, Saga Medical School, Japan.
Ann Hematol. 1995 Dec;71(6):319-23. doi: 10.1007/BF01697988.
Lymphoblastic lymphoma (LBL) is a highly malignant subtype of non-Hodgkin's lymphoma (NHL) and generally carries a T-cell phenotype with mediastinum or central nervous system (CNS) involvement. However, only a small proportion of LBL exhibit a B-cell phenotype (B-LBL), and these frequently present at the head and neck without mediastinum or CNS involvement. Three immunological subgroups may exist. The most predominant CD10-positive pre-B-cell type, corresponding to a precursor B-cell neoplasm, frequently involves the head and neck. The second, CD10-negative or mature B-cell type, defined by the absence of CD10 or presence of surface membrane immunoglobulins combined with expression of CD19 or CD20, often involves the mediastinum. The final group is a CD5-positive B-cell type corresponding to a blastic variant of mantle cell lymphoma (MCL). Its clinical course is less aggressive, patients are often older, and nodal lesions are more frequent than extranodal involvement. Thus, B-LBL is immunologically diverse, but its biological behavior correlates with the immunophenotype.
淋巴母细胞淋巴瘤（LBL）是非霍奇金淋巴瘤（NHL）的一种高度恶性亚型，通常具有T细胞表型，并累及纵隔或中枢神经系统（CNS）。然而，只有一小部分LBL表现为B细胞表型（B-LBL），这些病例常出现在头颈部，不累及纵隔或CNS。可能存在三个免疫亚组。最主要的是CD10阳性前B细胞型，对应于前体B细胞肿瘤，常累及头颈部。第二种是CD10阴性或成熟B细胞型，其定义为缺乏CD10或存在表面膜免疫球蛋白并伴有CD19或CD20表达，常累及纵隔。最后一组是CD5阳性B细胞型，对应于套细胞淋巴瘤（MCL）的母细胞变异型。其临床病程侵袭性较小，患者通常年龄较大，淋巴结病变比结外受累更常见。因此，B-LBL在免疫方面具有多样性，但其生物学行为与免疫表型相关。
