Patrizi A, Neri I, Passarini B, Varotti C
Department of Dermatology, University of Bologna, Italy.
Dermatology. 1995;191(3):264-7. doi: 10.1159/000246561.
Keratosis lichenoides chronica (KLC) is a rare chronic disorder of keratinization characterized by lichenoid hyperkeratotic papules arranged in a linear pattern, erythematosquamous plaques and seborrhea-like dermatitis on the face. Adults between 20 and 50 years of age are usually affected, but the disease is very uncommon in childhood. Our purpose was to study the clinical and histopathologic findings and course of KLC in one pediatric case. Detailed clinical data were studied. Two punch biopsies were performed and histopathologic features were compared with those of other reported cases of KLC. In our patient, a 4-year-old boy, the clinical features of the lesions did not deviate notably from those of other cases of KLC. The histologic pattern of the papules was typical of KLC, while that of the erythematosquamous plaques showed some dyskeratotic keratinocytes. The histologic pattern of the erythematosquamous lesions is peculiar in our case, whereas only a nonspecific pattern is reported in the literature. The papular and erythematosquamous lesions showed similar histopathologic features suggesting that they could be different degrees of evolution of the same lesion.
慢性苔藓样角化病（KLC）是一种罕见的角化异常慢性疾病，其特征为呈线状排列的苔藓样角化性丘疹、红斑鳞屑性斑块以及面部的脂溢性皮炎样表现。通常发病于20至50岁的成年人，但在儿童中极为罕见。我们的目的是研究1例儿科病例中KLC的临床、组织病理学表现及病程。对详细的临床资料进行了研究。进行了两次打孔活检，并将组织病理学特征与其他已报道的KLC病例进行了比较。我们的患者是一名4岁男孩，其皮损的临床特征与其他KLC病例并无显著差异。丘疹的组织学模式是KLC的典型表现，而红斑鳞屑性斑块的组织学模式显示出一些角化不良的角质形成细胞。在我们的病例中，红斑鳞屑性皮损的组织学模式较为特殊，而文献中仅报道过非特异性模式。丘疹和红斑鳞屑性皮损显示出相似的组织病理学特征，提示它们可能是同一皮损的不同程度演变。
