利用新型同源近交系定位小鼠3号染色体上的糖尿病多基因Idd3。
Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains.
作者信息
Lord C J, Bohlander S K, Hopes E A, Montague C T, Hill N J, Prins J B, Renjilian R J, Peterson L B, Wicker L S, Todd J A
机构信息
Nuffield Department of Surgery, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK.
出版信息
Mamm Genome. 1995 Sep;6(9):563-70. doi: 10.1007/BF00352359.
Development of novel congenic mouse strains has allowed us to better define the location of the diabetogenic locus, Idd3, on Chromosome (Chr) 3. Congenic strains were identified by use of published and newly developed microsatellite markers, their genomes fingerprinted by a rapid, fluorescence-based approach, and their susceptibility to type 1 diabetes evaluated. The maximum interval containing Idd3 is now approximately 4 cM.
新型同源近交系小鼠品系的培育使我们能够更好地确定位于第3号染色体上致糖尿病位点Idd3的位置。通过使用已发表的和新开发的微卫星标记来鉴定同源近交系，采用基于荧光的快速方法对其基因组进行指纹分析，并评估它们对1型糖尿病的易感性。目前，包含Idd3的最大区间约为4厘摩。
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