位于3号染色体上两个非主要组织相容性复合体连锁的胰岛素依赖型糖尿病位点Idd3和Idd10的抗性等位基因可保护非肥胖糖尿病小鼠不患糖尿病。
Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.
作者信息
Wicker L S, Todd J A, Prins J B, Podolin P L, Renjilian R J, Peterson L B
机构信息
Department of Autoimmune Diseases Research, Merck Research Laboratories, Rahway, New Jersey 07065.
出版信息
J Exp Med. 1994 Nov 1;180(5):1705-13. doi: 10.1084/jem.180.5.1705.
Abstract
Development of diabetes in NOD mice is polygenic and dependent on both major histocompatibility complex (MHC)-linked and non-MHC-linked insulin-dependent diabetes (Idd) genes. In (F1 x NOD) backcross analyses using the B10.H-2g7 or B6.PL-Thy1a strains as the outcross partner, we previously identified several non-MHC Idd loci, including two located on chromosome 3 (Idd3 and Idd10). In the current study, we report that protection from diabetes is observed in NOD congenic strains having B6.PL-Thy1a- or B10-derived alleles at Idd3 or Idd10. It is important to note that only partial protection is provided by two doses of the resistance allele at either Idd3 or Idd10. However, nearly complete protection from diabetes is achieved when resistance alleles are expressed at both loci. Development of these congenic strains has allowed Idd3 to be localized between Glut2 and D3Mit6, close to the Il2 locus.
摘要
非肥胖糖尿病（NOD）小鼠糖尿病的发生是多基因性的，依赖于主要组织相容性复合体（MHC）连锁和非MHC连锁的胰岛素依赖型糖尿病（Idd）基因。在以B10.H-2g7或B6.PL-Thy1a品系作为回交亲本的（F1×NOD）回交分析中，我们之前鉴定出了几个非MHC Idd位点，包括位于3号染色体上的两个位点（Idd3和Idd10）。在当前研究中，我们报告称，在Idd3或Idd10处具有B6.PL-Thy1a或B10衍生等位基因的NOD同源近交系小鼠中观察到了对糖尿病的抗性。需要注意的是，在Idd3或Idd10处，两剂抗性等位基因仅提供部分保护。然而，当两个位点都表达抗性等位基因时，几乎可以实现对糖尿病的完全保护。这些同源近交系的培育使得Idd3被定位在Glut2和D3Mit6之间，靠近Il2基因座。
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Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.位于3号染色体上两个非主要组织相容性复合体连锁的胰岛素依赖型糖尿病位点Idd3和Idd10的抗性等位基因可保护非肥胖糖尿病小鼠不患糖尿病。
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