Smith M R
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Leuk Lymphoma. 1995 Jul;18(3-4):209-14. doi: 10.3109/10428199509059609.
Prothymosin alpha is an acidic nuclear protein that is expressed at high levels in a wide variety of cell types. Accumulating data correlate prothymosin expression with alterations in the proliferative state of cells. Some data indicates that prothymosin may actually be necessary, if not sufficient, for proliferation, and that prothymosin may function in a c-myc associated pathway. Prothymosin is highly conserved through evolution suggesting a key function, however, that function remains unknown.
前胸腺素α是一种酸性核蛋白，在多种细胞类型中高水平表达。越来越多的数据表明前胸腺素的表达与细胞增殖状态的改变相关。一些数据表明，前胸腺素对于细胞增殖可能实际上是必要的（即便不是充分条件），并且前胸腺素可能在与c-myc相关的途径中发挥作用。前胸腺素在进化过程中高度保守，这表明它具有关键功能，然而该功能仍然未知。
