Zipursky A, Christensen H, De Harven E
Department of Paediatrics, Hospital for Sick Children, Toronto, Canada.
Leuk Lymphoma. 1995 Jul;18(3-4):341-7. doi: 10.3109/10428199509059628.
The ultrastructure of the leukemic cells in transient leukemia (six cases), myelodysplasia (five cases) and acute megakaryoblastic leukemia (one case) in patients with Down syndrome were studied. The cells were identified to be of megakaryocytic lineage by virtue of the expression of platelet glycoprotein GpIIIa, detected by immunogold labelling. In all patients, some of the leukemic cells had ultrastructural features of megakaryocytes, including ectoplasmic protrusions, demarcation membranes, and alpha granules. Differentiation was greatest in the cells of patients with transient leukemia. These studies provide a detailed assessment of the ultrastructural features of the leukemic cells in the megakaryoblastic leukemias of Down syndrome.
对唐氏综合征患者的短暂性白血病（6例）、骨髓增生异常综合征（5例）和急性巨核细胞白血病（1例）中的白血病细胞超微结构进行了研究。通过免疫金标记检测血小板糖蛋白GpIIIa的表达，确定这些细胞为巨核细胞系。在所有患者中，一些白血病细胞具有巨核细胞的超微结构特征，包括外质突起、分界膜和α颗粒。短暂性白血病患者的细胞分化程度最高。这些研究对唐氏综合征巨核细胞白血病中白血病细胞的超微结构特征进行了详细评估。
