Albert R E, Train R E, Anderson E
J Natl Cancer Inst. 1977 May;58(5):1537-41. doi: 10.1093/jnci/58.5.1537.
The intent of the Environmental Protection Agency's "Interim Guideline for Carcinogen Risk Assessment" is to provide an evaluation of the evidence regarding suspect carcinogens that encapsulates judgments on the quality and adequacy of data, the likelihood that the agent is a human carcinogen, and an estimate of the magnitude of the cancer burden that could be ascribed to the agent if no regulatory action were taken. Every effort shoult be made to reduce environmental contamination by carcinogens to the lowest possible level; this view stems from uncertainties about qualitative and quantitative extrapolations from animals to man, the lack of evidence for a dose threshold, the great range of possible interactions among environmental carcinogens and cofactors, and the broad spectrum of human susceptibility. New knowledge in the field of carcinogenesis is developing, and modifications of the Environmental Protection Agency's "Interim Guideline for Carcinogen Risk Assessment" must be made periodically.
美国环境保护局的《致癌物风险评估临时指南》旨在对有关可疑致癌物的证据进行评估，其中包括对数据质量和充分性的判断、该物质成为人类致癌物的可能性，以及如果不采取监管行动，可归因于该物质的癌症负担程度的估计。应尽一切努力将致癌物对环境的污染降至尽可能低的水平；这一观点源于从动物到人类的定性和定量推断存在不确定性、缺乏剂量阈值的证据、环境致癌物与辅助因素之间可能存在的大量相互作用，以及人类易感性的广泛范围。致癌作用领域的新知识不断发展，因此必须定期对美国环境保护局的《致癌物风险评估临时指南》进行修订。
