Hansson L, Petitet A
Department of Geriatrics, Clinical Hypertension Research, University of Uppsala, Sweden.
Blood Press Suppl. 1995;3:21-5.
Urapidil, an antihypertensive agent with dual action (alpha 1-adrenergic antagonist and 5HT1A agonist) is well established in the treatment of arterial hypertension. The present brief review deals specifically with data obtained with urapidil in the treatment of elderly hypertensive patients. Some of these data, dealing with 245 patients aged > or = 65 years, have previously been published, but additional data from more than 5000 hypertensive patients in this age group on file will be reviewed as well. This unique and large data base clearly indicates that urapidil is an effective antihypertensive agent also when used in the treatment of elderly patients. Moreover, urapidil is well tolerated in this age group and has, in addition, a potentially favourable lipid profile. It may therefore be concluded that urapidil is well suited for the treatment of hypertension in the elderly.
乌拉地尔是一种具有双重作用（α1肾上腺素能拮抗剂和5HT1A激动剂）的抗高血压药物，在动脉高血压治疗中已得到充分确立。本简要综述专门讨论了乌拉地尔治疗老年高血压患者所获得的数据。其中一些涉及245名年龄≥65岁患者的数据此前已发表，但也将回顾该年龄组档案中5000多名高血压患者的更多数据。这个独特且庞大的数据库清楚地表明，乌拉地尔用于治疗老年患者时也是一种有效的抗高血压药物。此外，乌拉地尔在该年龄组中耐受性良好，并且具有潜在有利的血脂谱。因此可以得出结论，乌拉地尔非常适合治疗老年人的高血压。
