Witte I, Jacobi H, Juhl-Strauss U
Carl von Ossietzky Universität Oldenburg.
Chemosphere. 1995 Nov;31(9):4041-9. doi: 10.1016/0045-6535(95)80005-6.
The cytotoxic combination effects of 2,4-D with 12 xenobiotics having different lipophilicity were investigated in human fibroblasts at their no effect concentrations (NOEC). Each of the chemicals tested in binary combinations enhanced the toxicity of 2,4-D. These synergistic combination effects were independent of the chemical structure of the test compounds. However, the NOEC's of the xenobiotics used in the combinations varied by a factor of 10,000. For strongly lipophilic compounds the lowest NOEC's were needed to induce synergistic cytotoxicity. A linear regression analysis of the concentrations (NOEC's) of the 12 combined xenobiotics against their lipophilicity revealed a correlation with r = 0.96 for 11 agents. This close correlation may be explained by the membrane damaging properties of lipophilic compounds which enhance the uptake of hydrophilic agents.
在人成纤维细胞的无效应浓度（NOEC）下，研究了2,4-二氯苯氧乙酸（2,4-D）与12种具有不同亲脂性的异生物质的细胞毒性联合效应。二元组合中测试的每种化学物质都增强了2,4-D的毒性。这些协同联合效应与测试化合物的化学结构无关。然而，组合中使用的异生物质的NOEC相差10000倍。对于强亲脂性化合物，诱导协同细胞毒性所需的NOEC最低。对12种联合异生物质的浓度（NOEC）与其亲脂性进行线性回归分析，发现11种物质的相关系数r = 0.96。这种密切相关性可能是由于亲脂性化合物的膜损伤特性增强了亲水性物质的摄取所致。
