患有慢性肺病的早产儿家庭中的呼吸道疾病。
Respiratory illness in families of preterm infants with chronic lung disease.
作者信息
de Winter J P, van Sonderen L, van den Anker J N, Merth I T, Brand R, van Bel F, Zonderland H M, Quanjer P H
机构信息
Leiden University, Department of Paediatrics, The Netherlands.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1995 Nov;73(3):F147-52. doi: 10.1136/fn.73.3.f147.
AIMS--To examine the relation, based on two types of questionnaires, between (1) chronic lung disease of the newborn (CLDN) and lower respiratory illness (LRI) in siblings, and between (2) CLDN and asthma, chronic obstruction pulmonary disease (COPD), or allergy in parents and grandparents. METHODS--Data from 209 children born before 32 weeks of gestation were randomly taken from the records of three neonatal units. Taking into account age and gender, the excess of LRI was calculated for each family compared with the average of all families. Subsequently whether CLDN was associated with an excess of LRI in the family was tested. RESULTS--Thirty one (14.8%) children were diagnosed as having CLDN. The family probability index for LRI did not differ between children with or without CLDN. The prevalence of COPD, asthma, and allergy in parents of children with CLDN was similar to that of children without CLDN. The prevalence of LRI was 18.1% in study children, 29.6% in children with CLDN, and 16.9% in children without CLDN (P < 0.01). These prevalences were higher compared with that of a group of term siblings (9.3%) (P = 0.05). CONCLUSIONS--These findings suggest that CLDN in preterm children is not related to a genetic or familial predisposition towards asthma, COPD, or allergy.
目的——基于两种问卷类型，研究（1）新生儿慢性肺部疾病（CLDN）与同胞下呼吸道疾病（LRI）之间的关系，以及（2）CLDN与父母及祖父母患哮喘、慢性阻塞性肺疾病（COPD）或过敏之间的关系。方法——从三个新生儿病房的记录中随机抽取209名孕周小于32周出生儿童的数据。考虑年龄和性别因素，计算每个家庭与所有家庭平均值相比的LRI超额情况。随后检验CLDN是否与家庭中LRI超额相关。结果——31名（14.8%）儿童被诊断为患有CLDN。有或无CLDN儿童的LRI家庭概率指数无差异。CLDN儿童父母中COPD、哮喘和过敏的患病率与无CLDN儿童相似。研究儿童中LRI患病率为18.1%，CLDN儿童中为29.6%，无CLDN儿童中为16.9%（P<0.01）。这些患病率高于一组足月儿同胞（9.3%）（P = 0.05）。结论——这些发现表明，早产儿的CLDN与哮喘、COPD或过敏的遗传或家族易感性无关。
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