年龄调节甲状腺功能障碍对性激素结合球蛋白（SHBG）水平的影响。

Age modulates effects of thyroid dysfunction on sex hormone binding globulin (SHBG) levels.

作者信息

Lecomte P, Lecureuil N, Lecureuil M, Osorio Salazar C, Valat C

机构信息

CHRU Bretonneau, France.

出版信息

Exp Clin Endocrinol Diabetes. 1995;103(5):339-42. doi: 10.1055/s-0029-1211375.

DOI:10.1055/s-0029-1211375

PMID:8536064

Abstract

Symptoms of thyroid dysfunction are difficult to detect in elderly people and TSH is sometimes unreliable. We therefore tested the value of SHBG as a marker of thyroid hormone action on the liver to determine the thyroid status of elderly people. Aging euthyroid men and women have a significant increase in SHBG (p > 0.0001). In aging women the decrease in SHBG with hypothyroidism and increase with hyperthyroidism are highly significant (p < 0.0001 and p < 0.0005 respectively). No significant variation in SHBG was observed in men with thyroid dysfunction. SHBG can help to determine the thyroid status of aging women.

摘要

甲状腺功能障碍的症状在老年人中很难被察觉，而且促甲状腺激素（TSH）有时也不可靠。因此，我们测试了性激素结合球蛋白（SHBG）作为甲状腺激素对肝脏作用的标志物的价值，以确定老年人的甲状腺状态。甲状腺功能正常的老年男性和女性的SHBG显著增加（p>0.0001）。在老年女性中，甲状腺功能减退时SHBG降低，甲状腺功能亢进时SHBG升高，差异非常显著（分别为p<0.0001和p<0.0005）。甲状腺功能障碍的男性中未观察到SHBG有显著变化。SHBG有助于确定老年女性的甲状腺状态。