Dumoulin S C, Perret B P, Bennet A P, Caron P J
Department of Endocrinology, CHU Rangueil, Toulouse, France.
Eur J Endocrinol. 1995 May;132(5):594-8. doi: 10.1530/eje.0.1320594.
Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or levothyroxine therapy (study 2). The SHBG levels are increased in hyper- and decreased in hypothyroid patients, whereas CBG levels are increased in hypo- and decreased in hyperthyroid patients. The SHBG levels are higher in women than in men with similar thyroid status. Plasma SHBG levels are correlated positively whereas CBG levels are correlated negatively with free thyroid hormone concentrations in men as well as women. In hypothyroid patients, SHBG concentrations increased (p < 0.01) and CBG concentrations decreased (p < 0.01) during levothyroxine treatment. In hyperthyroid patients, SHBG concentrations decreased (p < 0.01) and CBG concentrations increased (p < 0.01) during antithyroid treatment. The SHBG and CBG concentrations in treated hypo- and hyperthyroid patients were not significantly different from those of euthyroid controls. Our data indicate that SHBG and CBG levels depend on thyroid status. Corticosteroid-binding globulin is an index of thyroid hormone action at the liver level whose changes are opposite to those of SHBG in hyper- and hypothyroidism.
在甲状腺功能正常的男性（N = 111）、甲状腺功能亢进的男性（N = 58）和甲状腺功能减退的男性（N = 38）中，以及在绝经前和绝经后的女性中（研究1），还有在接受卡比马唑或左甲状腺素治疗前后的甲状腺功能亢进患者（N = 24）和甲状腺功能减退患者（N = 15）中（研究2），评估了性激素结合球蛋白（SHBG）和皮质类固醇结合球蛋白（CBG）水平。甲状腺功能亢进患者的SHBG水平升高，甲状腺功能减退患者的SHBG水平降低，而甲状腺功能减退患者的CBG水平升高，甲状腺功能亢进患者的CBG水平降低。在甲状腺状态相似的情况下，女性的SHBG水平高于男性。男性和女性的血浆SHBG水平与游离甲状腺激素浓度呈正相关，而CBG水平与游离甲状腺激素浓度呈负相关。在甲状腺功能减退患者中，左甲状腺素治疗期间SHBG浓度升高（p < 0.01），CBG浓度降低（p < 0.01）。在甲状腺功能亢进患者中，抗甲状腺治疗期间SHBG浓度降低（p < 0.01），CBG浓度升高（p < 0.01）。接受治疗的甲状腺功能减退和亢进患者的SHBG和CBG浓度与甲状腺功能正常的对照组无显著差异。我们的数据表明，SHBG和CBG水平取决于甲状腺状态。皮质类固醇结合球蛋白是甲状腺激素在肝脏水平作用的一个指标，其在甲状腺功能亢进和减退时的变化与SHBG相反。
