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龟分枝杆菌性角膜炎:清创术及预浸胶原盾片治疗后病情缓解

Mycobacterium chelonae keratitis: resolution after debridement and presoaked collagen shields.

作者信息

Lois N, Perez del Molino M L

机构信息

Department of Ophthalmology, Hospital General de Galicia-Clínico Universitario, Universidad de Santiago de Compostela, Spain.

出版信息

Cornea. 1995 Sep;14(5):536-9.

PMID:8536470
Abstract

We report a case of Mycobacterium chelonae keratitis following corneal injury by a foreign body. Diagnosis was made by Ziehl-Neelsen staining and Löwenstein-Jensen culture of corneal scrapings. On the basis of the in vitro susceptibility testing, the patient was treated with topical fortified amikacin. Given the lack of response to this therapy, we decided to carry out a debridement of the infiltrative areas to eliminate infected tissue, and to use an amikacin-soaked collagen shield supplemented every 4 h with topical fortified amikacin to promote healing of the debrided area and to potentiate the effects of the antibiotic therapy. After this treatment, clinical resolution was observed and a further acid-fast stain and culture for mycobacterium were negative. Debridement of the infiltrative areas could be used in cases of mycobacterium keratitis when early diagnosis is made and before the corneal infection has become widespread.

摘要

我们报告一例因异物导致角膜损伤后发生的龟分枝杆菌角膜炎病例。通过对角膜刮片进行萋-尼染色和罗氏培养作出诊断。根据体外药敏试验,对该患者使用局部强化阿米卡星进行治疗。鉴于对该治疗无反应,我们决定对浸润区域进行清创以清除感染组织,并使用每4小时补充一次局部强化阿米卡星的浸有阿米卡星的胶原盾,以促进清创区域的愈合并增强抗生素治疗的效果。经过该治疗后,观察到临床症状消退,进一步的抗酸染色和分枝杆菌培养结果为阴性。当早期诊断出分枝杆菌角膜炎且角膜感染尚未广泛扩散时,可对浸润区域进行清创。

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