Tarhan F, Ersev D, Aslan N, Ozgül A, Kuyumcuoğlu U, Oktay S
Urology Clinic, Kartal Education and Research Hospital, Istanbul, Turkey.
Eur Urol. 1995;28(3):255-8. doi: 10.1159/000475061.
The contractile effect of oxytocin on isolated rabbit corpus cavernosum strips was investigated. Concentration-response curves to oxytocin and phenylephrine were obtained. Oxytocin repetitively induced concentration-dependent contractions in the corpus cavernosum strips. The maximal contractile response to oxytocin was in amplitude 39.4 +/- 9.1% of that to phenylephrine. The slopes of the concentration-response curves, the amplitude of the maximal contractile effects, and the pD2 values of oxytocin obtained in endothelium-denuded strips were not significantly different from those of intact preparations. The results of this study demonstrated that oxytocin contracts the rabbit corpus cavernosum, but the endothelium does not contribute to this effect. Since oxytocin is less efficacious than phenylephrine, it seems unlikely that this hormone can serve as an alternative in the treatment of prolonged penile erections.
研究了催产素对离体兔海绵体条的收缩作用。获得了对催产素和去氧肾上腺素的浓度-反应曲线。催产素反复诱导海绵体条出现浓度依赖性收缩。催产素的最大收缩反应幅度为去氧肾上腺素的39.4±9.1%。在内皮剥脱条上获得的催产素浓度-反应曲线斜率、最大收缩效应幅度和pD2值与完整制剂的这些参数无显著差异。本研究结果表明，催产素可使兔海绵体收缩，但内皮对此效应无作用。由于催产素的效力低于去氧肾上腺素，该激素似乎不太可能作为治疗持续性阴茎勃起的替代药物。
