Gazca Aguilar A, del Río Navarro B, Sienra Monge J J, Linares Zapien F J
Adscrito al servicio de alergia e inmunología clínica, Hospital Infantil de México Federico Gómez México, D.F.
Ginecol Obstet Mex. 1995 Nov;63:460-6.
Asthma is among the diseases that may complicate pregnancy. Asthma affects up to 4% of the pregnant women. Uncontrolled asthma may impair the proper oxygenation of both mother and child. According to asthma severity clinical manifestations may be unapparent or apparent requiring hospital treatment. It is necessary that pregnant asthmatic woman check daily the peak-flow by portable peak-flow meters. The asthma pharmacological treatment should consider the changes in the physiology of the pregnancy, such as low albumin and carrier proteins for the drugs inducing high levels of free active drugs. This point is important for theophylline, besides the low drug clearance. Bronchodilator should be used as they are required, using the inhaled forms, as well as short term corticoid courses. The goal of the treatment is to control the symptoms, avoid relapse and keep the ventilatory function close to the normal, in order to achieve a satisfactory state of the mother and the children.
哮喘是可能使妊娠复杂化的疾病之一。哮喘影响多达4%的孕妇。未得到控制的哮喘可能会损害母婴的正常氧合。根据哮喘的严重程度，临床表现可能不明显或明显到需要住院治疗。怀孕的哮喘妇女有必要每天用便携式峰值流量计检查峰值流量。哮喘的药物治疗应考虑到妊娠生理的变化，如白蛋白和药物载体蛋白水平较低，导致游离活性药物水平升高。除了药物清除率低之外，这一点对茶碱很重要。应根据需要使用支气管扩张剂，采用吸入剂型以及短期皮质类固醇疗程。治疗的目标是控制症状，避免复发，并使通气功能接近正常，以实现母婴的满意状态。
