Liang C Y, Yang Y, Khadim M A, Banker G S, Kumar V
Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City 52242, USA.
J Pharm Sci. 1995 Sep;84(9):1141-3. doi: 10.1002/jps.2600840921.
Dyclonine hydrochloride, a local anesthetic, is known to degrade in aqueous media. In this paper, the isolation and characterization of two major degradation products, formed by heating of an aqueous solution of dyclonine hydrochloride for 2 weeks at 50 degrees C, are presented. The proton and carbon-13 nuclear magnetic resonance, infrared, and mass spectral data reported conclusively show the two products to be 1-(4-butoxyphenyl)-2-propen-1-one and 1-(4-butoxyphenyl)-3-hydroxy-1-propanone. The proton and carbon-13 nuclear magnetic resonance spectral data of the free dyclonine base are also included.
盐酸达克罗宁是一种局部麻醉剂，已知其在水性介质中会降解。本文介绍了通过将盐酸达克罗宁水溶液在50℃加热2周形成的两种主要降解产物的分离与表征。所报道的质子和碳-13核磁共振、红外和质谱数据确凿地表明这两种产物分别为1-(4-丁氧基苯基)-2-丙烯-1-酮和1-(4-丁氧基苯基)-3-羟基-1-丙酮。文中还包括了游离达克罗宁碱的质子和碳-13核磁共振光谱数据。
