Shah S, Cole M D, Nicholls A
Royal Eye Hospital, Manchester, England, UK.
J R Soc Med. 1995 Oct;88(10):597P-598P.
Sarcoidosis commonly presents in young adults with bilateral hilar lymphadenopathy, lung parenchymal disease and/or skin lesions. Ocular symptoms are the presenting feature in up to 10% of cases, but eye involvement can be demonstrated in around a quarter of all patients. Renal disease is much rarer, and may manifest with hypercalcaemic nephropathy, granulomatous interstitial nephritis, tubular dysfunction or glomerulonephritis. Eye and renal involvement are rarely found together, and may be confused with Wegener's granulomatosis or polyarteritis. We report a case of a young man who developed renal failure due to sarcoidosis soon after presenting with uveitis. The case illustrates an unusual combination of systemic features that may not be widely recognized.
结节病常见于年轻成人，表现为双侧肺门淋巴结肿大、肺实质病变和/或皮肤损害。眼部症状在高达10%的病例中为首发特征，但在所有患者中约四分之一可出现眼部受累。肾脏疾病则更为罕见，可表现为高钙血症性肾病、肉芽肿性间质性肾炎、肾小管功能障碍或肾小球肾炎。眼部和肾脏受累很少同时出现，可能会与韦格纳肉芽肿或结节性多动脉炎相混淆。我们报告一例年轻男性病例，该患者在出现葡萄膜炎后不久因结节病发展为肾衰竭。该病例说明了一种可能未被广泛认识的不寻常的全身特征组合。
