Penny G D, Kay G F, Sheardown S A, Rastan S, Brockdorff N
Section of Comparative Biology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Nature. 1996 Jan 11;379(6561):131-7. doi: 10.1038/379131a0.
The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.
Xist基因已被提出作为X染色体失活中心的候选基因，X染色体失活中心是控制X染色体失活的主要调控开关位点。到目前为止，这一假说仅得到间接证据的支持。在此，我们描述了Xist基因的靶向性，并为其在X染色体失活过程中的绝对必要性提供了证据。
