Colotto A, Salgarello T, Giudiceandrea A, De Luca L A, Coppè A, Buzzonetti L, Falsini B
Eye Clinic, Catholic University, Rome, Italy.
Ophthalmic Res. 1995;27(3):168-77. doi: 10.1159/000267663.
To investigate pattern electroretinogram changes in treated ocular hypertension, we evaluated pattern electroretinogram recordings of 48 hypertensive eyes following an 8-month timolol maleate therapy. During treatment, 27 of 48 eyes had normalized intraocular pressures (15-18 mm Hg), while 21 retained elevated values (21-25 mm Hg). Twenty-eight eyes with untreated hypertension (22-25 mm Hg) lasting at least 8 months, as well as 32 untreated, normotensive eyes served as controls. When compared to untreated normotensive controls, timolol-treated eyes with either elevated or normalized intraocular pressures showed reductions in the mean electroretinographic amplitudes. However, these amplitude reductions were substantially greater in treated eyes with elevated pressures as compared to those with normalized ones. Untreated hypertensive controls showed pattern electroretinogram reductions, with respect to normal values, that were comparable to those of treated hypertensive eyes, but larger than those of treated normotensive ones. These results indicate that, in treated ocular hypertension, pattern electroretinogram losses tend to be associated with moderately increased intraocular pressures in the range of 21-25 mm Hg. Electroretinographic abnormalities may be, at least in part, prevented only by lowering intraocular pressure into a normal range.
为了研究治疗性高眼压症患者的图形视网膜电图变化，我们评估了48只高血压患眼在接受8个月的马来酸噻吗洛尔治疗后的图形视网膜电图记录。治疗期间，48只眼中有27只眼的眼压恢复正常（15 - 18毫米汞柱），而21只眼的眼压仍保持升高（21 - 25毫米汞柱）。28只未经治疗的高血压患眼（眼压22 - 25毫米汞柱，病程至少8个月）以及32只未经治疗的血压正常的眼睛作为对照。与未经治疗的血压正常的对照相比，马来酸噻吗洛尔治疗后眼压升高或恢复正常的患眼的视网膜电图平均振幅均降低。然而，与眼压恢复正常的患眼相比，眼压升高的患眼的振幅降低幅度要大得多。未经治疗的高血压对照的图形视网膜电图相对于正常值也有所降低，其降低程度与治疗后的高血压患眼相当，但大于治疗后的血压正常的患眼。这些结果表明，在治疗性高眼压症中，图形视网膜电图的损失往往与眼压在21 - 25毫米汞柱范围内适度升高有关。视网膜电图异常可能至少部分地只有通过将眼压降至正常范围才能预防。
