Shui Y B, Kojima M, Hockwin O, Sasaki K
Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Ophthalmic Res. 1995;27(3):178-86. doi: 10.1159/000267666.
In order to induce steroid cataracts in rat lenses, prednisolone acetate was administered together with a single subliminal dose of X-irradiation, which was applied unilaterally before steroid application started. The rats were divided into a control group (without prednisolone acetate administration), a group with a topically administered daily dose of 1 mg/kg prednisolone acetate suspension and a group with a systemically applied daily dose of 0.8-1.0 mg/kg prednisolone acetate suspension. Changes in the lens were objectively evaluated with in vivo Scheimpflug slit images during a 30-week period. Although body weight increase was significantly affected in both groups administered prednisolone, animals survived until the end of the observation period. The initial changes in the lens were the dissociation of the Y-suture and a slight increase in scattering light intensity at the posterior embryonic nucleus after both topical and systemic steroid administration.
为了在大鼠晶状体中诱发类固醇性白内障，在开始应用类固醇之前，先单侧给予单次阈下剂量的X射线照射，同时给予醋酸泼尼松龙。将大鼠分为对照组（未给予醋酸泼尼松龙）、局部每日给予1mg/kg醋酸泼尼松龙混悬液的组和全身每日给予0.8 - 1.0mg/kg醋酸泼尼松龙混悬液的组。在30周期间，通过体内Scheimpflug裂隙图像对晶状体的变化进行客观评估。虽然给予泼尼松龙的两组大鼠体重增加均受到显著影响，但动物存活至观察期结束。局部和全身给予类固醇后，晶状体的初始变化是Y缝解离以及胚胎后核处散射光强度略有增加。
