Cowan D F, Orihuela E, Motamedi M, Pow-Sang M, Tbakhi A, LaHaye M
Department of Pathology, University of Texas Medical Branch, Galveston, USA.
Mod Pathol. 1995 Sep;8(7):716-21.
High levels of applied laser irradiation to the prostate will carbonize or vaporize tissue, and may cause explosive expansion of superheated tissue water. Lower levels, used most often to relieve obstruction caused by benign prostatic hypertrophy, will cause coagulation necrosis. This effect is apparent within 1 h of application. In contrast to the canine, in which laser-coagulated prostate sloughs in 2 to 3 weeks leaving a smooth cavity, in the human necrotic tissue is sloughed irregularly over a period ranging up to 12 weeks. This difference is attributed to the dominantly glandular nature of the canine prostate, and the dense fibromuscular composition of the human prostate stroma. Sloughing is accomplished by surface liquefaction, cavitation of the necrotic coagulum, and to a lesser degree, formation of granulation tissue at the margins. As often occurs at the margin of spontaneous infarcts in the prostate, squamous metaplasia may be prominent at the margins of laser-induced coagulation necrosis.
对前列腺施加高强度激光照射会使组织碳化或汽化，并可能导致过热的组织水分发生爆炸性膨胀。较低强度的激光照射（最常用于缓解良性前列腺增生引起的梗阻）会导致凝固性坏死。这种效应在照射后1小时内就很明显。与犬类不同，犬类的激光凝固前列腺在2至3周内会脱落，留下一个光滑的腔，而人类坏死组织在长达12周的时间内会不规则地脱落。这种差异归因于犬类前列腺主要为腺性，而人类前列腺基质为致密的纤维肌肉组成。脱落在表面液化、坏死凝块的空化作用下完成，在较小程度上，还通过边缘肉芽组织的形成来完成。正如在前列腺自发性梗死边缘经常发生的情况一样，鳞状化生在激光诱导的凝固性坏死边缘可能很明显。
