Pow-Sang M, Orihuela E, Motamedi M, Pow-Sang J E, Cowan D F, Dyer R, Warren M M
Department of Surgery, University of Texas Medical Branch, Galveston, USA.
Urology. 1995 May;45(5):790-4. doi: 10.1016/S0090-4295(99)80085-5.
To evaluate the safety and efficacy of low-power slow-heating diode laser-induced photocoagulation of prostatic tissue for treatment of benign prostatic hyperplasia, we conducted a series of acute and chronic studies using a diode laser (810 nm) to irradiate human prostate.
The study included 6 patients undergoing radical prostatectomy because of malignancy. Laser radiation to the prostate was given transurethrally, in a noncontact mode, at the time of the procedure in 2 patients (acute group): 10 W for 300 seconds on the right side of the prostate and 15 W for 180 seconds on the left. In the remaining 4 patients (chronic group), laser radiation was given at 1, 7, 10, and 12 weeks prior to the prostatectomy.
In the acute group the average depth of coagulation was 8.5 and 9.0 mm for the laser regimens of 15 W for 180 seconds and the 10 W for 300 seconds, respectively. In the chronic group, the average depth of coagulation was 8.9 mm for both laser regimens studied. In the acute group, there was an ill-defined hemorrhagic ring at the periphery of the lesion. At 1 week, an intact necrotic coagulum was present. At 7 weeks, some of the coagulated tissue had already sloughed off. Longer follow-up at 10 and 12 weeks demonstrated formation of a well-defined cavity with mostly re-epithelialized surface.
Our findings suggest that noncontact diode laser (810 nm) irradiation can induce in the human prostate significant coagulation necrosis followed by sloughing of tissue and cavitation of the prostatic urethra.
为评估低功率慢热型二极管激光诱导前列腺组织光凝治疗良性前列腺增生的安全性和有效性，我们使用二极管激光（810纳米）对人类前列腺进行了一系列急性和慢性研究。
该研究纳入了6例因恶性肿瘤接受根治性前列腺切除术的患者。在手术过程中，对2例患者（急性组）经尿道以非接触模式对前列腺进行激光照射：1例患者前列腺右侧10瓦照射300秒，另1例患者前列腺左侧15瓦照射180秒。其余4例患者（慢性组）在前列腺切除术前1、7、10和12周接受激光照射。
急性组中，15瓦照射180秒和10瓦照射300秒的激光治疗方案的平均凝固深度分别为8.5毫米和9.0毫米。慢性组中，所研究的两种激光治疗方案的平均凝固深度均为8.9毫米。急性组中，病变周边有界限不清的出血环。1周时，有完整的坏死凝块。7周时，部分凝固组织已脱落。在10周和12周的更长时间随访中，可见形成界限清晰的腔隙，表面大多重新上皮化。
我们的研究结果表明，非接触式二极管激光（810纳米）照射可在人类前列腺中诱导显著的凝固性坏死，随后组织脱落和前列腺尿道空化。
