Martin W H, Delbeke D, Patton J A, Sandler M P
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-2675, USA.
Radiology. 1996 Jan;198(1):225-31. doi: 10.1148/radiology.198.1.8539384.
To compare single photon emission computed tomography (SPECT) with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) with FDG to evaluate malignancies.
PET and SPECT, with fluorine-18 sodium fluoride, were performed sequentially in a cylindric phantom that contained different size spheres with activity ratios of 5:1, 10:1, and 15:1. PET and SPECT were also performed in 24 patients with known or suspected malignancies.
Sensitivities of PET and SPECT were 2,238 cpm/microCi (82.8 cpm/MBq) and 129 cpm/microCi (4.8 cpm/MBq), respectively (reconstructed spatial resolution, 7 and 17 mm, respectively [13-cm radius of rotation]). In the phantom studies, lesions of 1.5 and 1.3 cm or more in diameter were detected with a ratio of 5:1 and 10:1, respectively, and an information density of 150 counts per square centimeter. At FDG PET, 46 hypermetabolic lesions consistent with tumor were depicted in patients; at FDG SPECT, 36 (78%) were depicted. Sensitivity of FDG SPECT was 92% for detection of malignancies 1.8 cm or more in diameter seen at FDG PET.
Findings at FDG SPECT can help differentiate benign from malignant lesions.
比较使用2-[氟-18]氟-2-脱氧-D-葡萄糖（FDG）的单光子发射计算机断层扫描（SPECT）和使用FDG的正电子发射断层扫描（PET）来评估恶性肿瘤。
在一个圆柱形体模中依次进行PET和使用氟-18氟化钠的SPECT检查，该体模包含不同大小的球体，其活度比为5:1、10:1和15:1。还对24例已知或疑似恶性肿瘤的患者进行了PET和SPECT检查。
PET和SPECT的灵敏度分别为2238 cpm/微居里（82.8 cpm/MBq）和129 cpm/微居里（4.8 cpm/MBq）（重建空间分辨率分别为7毫米和17毫米[旋转半径13厘米]）。在体模研究中，分别以5:1和10:1的活度比以及每平方厘米150计数的信息密度检测到直径为1.5厘米及1.3厘米或更大的病变。在FDG PET检查中，患者体内显示出46个与肿瘤一致的高代谢病变；在FDG SPECT检查中，显示出36个（78%）。FDG SPECT对FDG PET所见直径1.8厘米或更大的恶性肿瘤的检测灵敏度为92%。
FDG SPECT的检查结果有助于鉴别良性和恶性病变。
