68Ga-DOTATOC正电子发射断层扫描（PET）与111铟-二乙三胺五醋酸奥曲肽（Octreoscan）单光子发射计算机断层扫描（SPECT）在神经内分泌肿瘤患者中的比较。
Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours.
作者信息
Buchmann I, Henze M, Engelbrecht S, Eisenhut M, Runz A, Schäfer M, Schilling T, Haufe S, Herrmann T, Haberkorn U
机构信息
Department of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
出版信息
Eur J Nucl Med Mol Imaging. 2007 Oct;34(10):1617-26. doi: 10.1007/s00259-007-0450-1. Epub 2007 May 23.
PURPOSE
Neuroendocrine tumours (NETs) can be imaged with scintigraphy using radiolabelled somatostatin analogues. The aim of our study was to compare the value of (68)Ga-DOTATOC PET and (111)In-DTPAOC SPECT (Octreoscan) in the detection of NET manifestations.
METHODS
Twenty-seven NET patients were prospectively examined. (68)Ga-DOTATOC PET and (111)In-DTPAOC SPECT were performed using standard techniques. Treatment was not applied in between. Mean and maximum standardised uptake values (SUVs) were calculated for PET findings. Tumour/non-tumour ratios were calculated for SPECT findings. Findings were compared by a region-by-region analysis and verified with histopathology, CT and MRI within 21 days.
RESULTS
SUVs of positive lesions on (68)Ga-DOTATOC PET ranged from 0.7 to 29.3 (mean SUV) and from 0.9 to 34.4 (maximum SUV). Tumour/non-tumour ratios on (111)In-DTPAOC SPECT ranged from 1.8 to 7.3. In imaging lung and skeletal manifestations, (68)Ga-DOTATOC PET was more efficient than (111)In-DTPAOC SPECT. All discrepant lung findings and 77.8% of discrepant osseous findings were verified as true positive PET interpretations. In regional comparison of liver and brain, (68)Ga-DOTATOC PET and (111)In-DTPAOC SPECT were identical. In lymph nodes, the pancreas and the gastro-intestinal system, different values of the two techniques were not indicated in regional analyses. In a single patient, surgical interventions were changed on the basis of (68)Ga-DOTATOC PET findings.
CONCLUSION
(68)Ga-DOTATOC PET is superior to (111)In-DTPAOC SPECT in the detection of NET manifestations in the lung and skeleton and similar for the detection of NET manifestations in the liver and brain. (68)Ga-DOTATOC PET is advantageous in guiding the clinical management.
目的
神经内分泌肿瘤（NETs）可通过使用放射性标记的生长抑素类似物的闪烁显像进行成像。本研究的目的是比较（68）Ga-DOTATOC PET和（111）In-DTPAOC SPECT（奥曲肽扫描）在检测NET表现方面的价值。
方法
对27例NET患者进行前瞻性检查。使用标准技术进行（68）Ga-DOTATOC PET和（111）In-DTPAOC SPECT检查。在此期间未进行治疗。计算PET检查结果的平均和最大标准化摄取值（SUVs）。计算SPECT检查结果的肿瘤/非肿瘤比值。通过逐区域分析比较结果，并在21天内用组织病理学、CT和MRI进行验证。
结果
（68）Ga-DOTATOC PET上阳性病变的SUVs范围为0.7至29.3（平均SUV）和0.9至34.4（最大SUV）。（111）In-DTPAOC SPECT上的肿瘤/非肿瘤比值范围为1.8至7.3。在成像肺部和骨骼表现方面，（68）Ga-DOTATOC PET比（111）In-DTPAOC SPECT更有效。所有肺部差异发现和77.8%的骨骼差异发现被证实为PET的真阳性解释。在肝脏和脑的区域比较中，（68）Ga-DOTATOC PET和（111）In-DTPAOC SPECT结果相同。在淋巴结、胰腺和胃肠系统中，两种技术在区域分析中未显示出不同的值。在一名患者中，基于（68）Ga-DOTATOC PET检查结果改变了手术干预措施。
结论
（68）Ga-DOTATOC PET在检测肺部和骨骼的NET表现方面优于（111）In-DTPAOC SPECT，在检测肝脏和脑的NET表现方面与之相似。（68）Ga-DOTATOC PET在指导临床管理方面具有优势。
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