新型东方医学处方 TJS - 010 可拮抗丁苯那嗪诱导的大鼠自发运动活动抑制。
TJS-010, a new prescription of oriental medicine, antagonizes tetrabenazine-induced suppression of spontaneous locomotor activity in rats.
作者信息
Tanra A J, Kagaya A, Okamoto Y, Muraoka M, Motohashi N, Yamawaki S
机构信息
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1995 Sep;19(5):963-71. doi: 10.1016/0278-5846(95)00124-e.
PMID:8539432
Abstract
- The authors have determined the effect of TJS-010, a new prescription of oriental medicine, on the locomotor activity in rats. 2. Tetrabenazine(TBZ) decreased the spontaneous locomotion in rats, and attenuated the contents of amines and increased their metabolism in various regions in rat brain. 3. TJS-010 inhibited the locomotor suppression induced by TBZ: however, neither amine contents nor their metabolism was not altered, which suggested that TJS-010 postsynaptically modulated the transmission or transduction. 4. Imipramine also inhibited the decrease in locomotion induced by TBZ. 5. These results suggest a possibility that TJS-010 has an antidepressive effect.
摘要
- 作者们已经确定了一种新型东方医学处方TJS - 010对大鼠运动活性的影响。2. 丁苯那嗪（TBZ）降低了大鼠的自发运动，并减弱了大鼠脑内各个区域的胺含量，同时增加了它们的代谢。3. TJS - 010抑制了由TBZ诱导的运动抑制：然而，胺含量及其代谢均未改变，这表明TJS - 010在突触后调节了传递或转导。4. 丙咪嗪也抑制了由TBZ引起的运动减少。5. 这些结果表明TJS - 010具有抗抑郁作用的可能性。
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