Lopez M, Rinaldi M
Istituto Regina Elena per lo Studio e la Cura dei Tumori, Roma.
Riv Eur Sci Med Farmacol. 1994 Sep-Dec;16 Suppl 1:31-7.
Primary gastric lymphoma is the most frequent non-Hodgkin's lymphoma (NHL) of extranodal origin (25%). It accounts for 5% of all NHL and 4% of primary gastric malignancies. Recent studies suggest its origin from B-cell immune system. The majority of these tumors are high-grade centroblastic and immunoblastic subtype. The extent of disease is by far the most important guide to prognosis. Patients with gastric lymphoma usually recur in the gastrointestinal tract, but one-half of those recurring in abdomen also have tumor spread to extra-abdominal sites. Gastrectomy as a single treatment modality cures about one-third of patients with gastric lymphoma. The role of adjuvant therapy both in terms of radiotherapy and chemotherapy is not sufficiently known. In advanced stage when chemotherapy is indicated, CHOP combination seems to be appropriate in favorable prognostic situation, whereas aggressive third-generation combinations should be used for unfavorable cases.
原发性胃淋巴瘤是最常见的结外起源非霍奇金淋巴瘤（NHL）（占25%）。它占所有NHL的5%，占原发性胃恶性肿瘤的4%。最近的研究表明其起源于B细胞免疫系统。这些肿瘤大多数是高级别中心母细胞性和免疫母细胞性亚型。疾病范围是迄今为止最重要的预后指标。胃淋巴瘤患者通常在胃肠道复发，但腹部复发的患者中有一半肿瘤也扩散到腹部外部位。胃切除术作为单一治疗方式可治愈约三分之一的胃淋巴瘤患者。辅助放疗和化疗的作用尚不完全清楚。在晚期需要化疗时，CHOP方案在预后良好的情况下似乎适用，而预后不良的病例应使用积极的第三代联合方案。
