Steiger A
Max-Planck-Institut für Psychiatrie, Klinisches Institut, Psychiatrische Klinik, München.
Schweiz Med Wochenschr. 1995 Dec 2;125(48):2338-45.
Human sleep is characterized by the cyclic occurrence of nonREM and REM periods and by distinct patterns of nocturnal hormone secretion. A host of factors may result in disturbed sleep, including normal aging and depression. In both states, similar changes in sleep-endocrine activity occur, including decreases in slow wave sleep and in growth hormone secretion. Preclinical investigations and studies by our laboratory in young and elderly normal controls and in patients with depression demonstrate that neuropeptides play a key role in sleep regulation. As an example, growth hormone-releasing hormone (GHRH) is a common stimulus of slow wave sleep and growth hormone release, whereas corticotropin-releasing hormone (CRH) exerts opposite effects. We suggest that an imbalance of both peptides in favor of CRH contributes to changes in sleep-endocrine activity during depression and aging.
人类睡眠的特点是快速眼动（REM）期和非快速眼动（nonREM）期循环出现，以及夜间激素分泌的独特模式。许多因素可能导致睡眠障碍，包括正常衰老和抑郁症。在这两种状态下，睡眠-内分泌活动都会发生类似变化，包括慢波睡眠和生长激素分泌减少。我们实验室对年轻和老年正常对照者以及抑郁症患者进行的临床前研究表明，神经肽在睡眠调节中起关键作用。例如，生长激素释放激素（GHRH）是慢波睡眠和生长激素释放的常见刺激物，而促肾上腺皮质激素释放激素（CRH）则产生相反的作用。我们认为，两种肽以CRH为主导的失衡导致了抑郁症和衰老过程中睡眠-内分泌活动的变化。
