Schaff Z, Lapis K, Kereztury S, Kolláth Z
Morphol Igazsagugyi Orv Sz. 1977 Feb;17(1):33-7.
Needle-hepatic-biopsy of 10 patients with acute viral hepatitis was investigated by the aid of electron microscope. In the hepatocytes striking nucleolar alterations were observed, i.e. breakage and dispersion of the nucleolonema in the karyoplasma. Not infrequently nuclear bodies were seen. According to the present knowledge it can not be decided whether nuclear bodies are normal constituents of the hepatocytes or product of the impaired function. Complex nuclear bodies--in acute viral hepatitis--might indicate the presence of viral infection, on the other hand they might be the sign of the disturbance of the nuclear RNS-synthesis.
借助电子显微镜对10例急性病毒性肝炎患者进行了肝穿刺活检。在肝细胞中观察到明显的核仁改变，即核仁丝在核质中断裂和分散。核体也屡见不鲜。根据目前的知识，尚无法确定核体是肝细胞的正常成分还是功能受损的产物。在急性病毒性肝炎中，复杂的核体一方面可能表明存在病毒感染，另一方面也可能是核RNA合成紊乱的迹象。
