心肌中结构、功能与物质运输的整合

Integration of structure, function and mass transport in the myocardium.

作者信息

Zinemanas D, Beyar R, Sideman S

机构信息

Julius Silver Institute, Department of Biomedical Engineering, Technion-IIT, Haifa, Israel.

出版信息

Adv Exp Med Biol. 1995;382:279-92. doi: 10.1007/978-1-4615-1893-8_28.

DOI:10.1007/978-1-4615-1893-8_28

PMID:8540405

Abstract

A left ventricular (LV) model that integrates muscle mechanics, coronary flow, and fluid transport, and accounts for the three-phase (fiber-blood-interstitium) myocardial structure and composition, is used to study the interactions between the mechanics, coronary flow and fluid and mass transport in the myocardium. Theoretical simulations elucidate the effects of ventricular load, coronary perfusion pressure, and fluid and mass transport on ventricular performance and coronary dynamics. The analysis yields a direct relation between cardiac function and structure to cardiac mechanics, coronary flow, and intramyocardial fluid (and mass) transport, and allows to study the interactions between coronary flow, ventricular and myocardial mechanics and intramyocardial fluid shifts.

摘要

一个整合了肌肉力学、冠状动脉血流和液体传输，并考虑了三相（纤维-血液-间质）心肌结构和组成的左心室（LV）模型，被用于研究心肌力学、冠状动脉血流以及液体和物质传输之间的相互作用。理论模拟阐明了心室负荷、冠状动脉灌注压力以及液体和物质传输对心室功能和冠状动脉动力学的影响。该分析得出了心脏功能和结构与心脏力学、冠状动脉血流以及心肌内液体（和物质）传输之间的直接关系，并能够研究冠状动脉血流、心室和心肌力学以及心肌内液体转移之间的相互作用。