Ivy D D, Kinsella J P, Wolfe R R, Abman S H
Department of Pediatrics, University of Colorado School of Medicine, Denver, USA.
Am J Cardiol. 1996 Jan 1;77(1):102-5. doi: 10.1016/s0002-9149(97)89147-3.
ANP causes pulmonary vasodilation in some children with pulmonary hypertension secondary to congenital heart disease. In a small group of patients, ANP lowered mean pulmonary artery pressure and pulmonary vascular resistance index > 20% without changing systemic vascular resistance index. Inhaled NO is an effective pulmonary vasodilator and is a more selective pulmonary vasodilator than ANP. The utility of ANP may be limited by its nonselective effects as more selective vasodilator agents are available.
心房钠尿肽可使一些患有先天性心脏病继发肺动脉高压的儿童出现肺血管舒张。在一小部分患者中，心房钠尿肽可使平均肺动脉压和肺血管阻力指数降低超过20%，而全身血管阻力指数不变。吸入一氧化氮是一种有效的肺血管舒张剂，并且比心房钠尿肽更具肺血管舒张选择性。由于有了更具选择性的血管舒张剂，心房钠尿肽的效用可能会因其非选择性作用而受到限制。
