Deutsch J C, Santhosh-Kumar C R, Kolli V R
Veterans Administration Hospital, Denver, Colorado, USA.
Am J Gastroenterol. 1995 Dec;90(12):2182-5.
To determine if a single-step noninvasive stable isotope method of assessing digestive function could separate normal subjects from subjects with pancreatic insufficiency (maldigestion) or small bowel dysfunction (malabsorption) and to see if subjects with maldigestion could be simultaneously separated from subjects with malabsorption.
Forty (40) normal volunteers, 18 adults with cystic fibrosis and four adults with celiac sprue, ingested a liquid test meal along with bentiromide, [13C6]PABA, and xylose (PABAX test). Serum was collected at 1 h and analyzed for PABA, [13C6]PABA, and xylose by stable isotope dilution methods using gas chromatography mass spectrometry.
All subjects with cystic fibrosis had abnormal pancreatic function test results, whereas three of four adults with sprue had normal values of pancreatic function. All subjects with sprue had abnormal small bowel absorption tests, whereas all adults with cystic fibrosis had apparently normal intestinal function.
The one-step, 1-h PABAX test can reliably separate normal subjects from those with either maldigestion or malabsorption and can also separate subjects with maldigestion from those with malabsorption.
确定一种评估消化功能的单步非侵入性稳定同位素方法能否将正常受试者与胰腺功能不全（消化不良）或小肠功能障碍（吸收不良）受试者区分开来，以及能否将消化不良受试者与吸收不良受试者同时区分开来。
40名正常志愿者、18名成年囊性纤维化患者和4名成年乳糜泻患者摄入含苯替酪胺、[13C6]对氨基苯甲酸（PABA）和木糖的液体试验餐（PABAX试验）。1小时后采集血清，采用气相色谱质谱联用的稳定同位素稀释法分析血清中的PABA、[13C6]PABA和木糖。
所有囊性纤维化患者的胰腺功能测试结果均异常，而4名乳糜泻成年患者中有3名胰腺功能值正常。所有乳糜泻患者的小肠吸收试验均异常，而所有成年囊性纤维化患者的肠道功能显然正常。
单步1小时PABAX试验能够可靠地将正常受试者与消化不良或吸收不良受试者区分开来，也能够将消化不良受试者与吸收不良受试者区分开来。
