糖尿病胃轻瘫患者中环丙沙星的吸收情况。
Absorption of ciprofloxacin in patients with diabetic gastroparesis.
作者信息
Marangos M N, Skoutelis A T, Nightingale C H, Zhu Z, Psyrogiannis A G, Nicolau D P, Bassaris H P, Quintiliani R
机构信息
Department of Pharmacy, Hartford Hospital, Connecticut 06115, USA.
出版信息
Antimicrob Agents Chemother. 1995 Sep;39(9):2161-3. doi: 10.1128/AAC.39.9.2161.
The purpose of this study was to assess the pharmacokinetic profile of ciprofloxacin in 12 patients with diabetic gastroparesis. Patients received both a single 500-mg oral (p.o.) dose and a single 400-mg intravenous (i.v.) dose of ciprofloxacin separated by a 1-week washout period. Pharmacokinetic parameters (means +/- standard deviations) for the p.o. and i.v. doses were as follows: areas under the concentration-time curve from 0 h to infinity, 9.74 +/- 2.59 and 11.78 +/- 3.18 micrograms.h/ml, respectively; maximum concentrations of drug in serum, 2.13 +/- 0.67 and 4.21 +/- 1.07 micrograms/ml, respectively; and half-lives, 4.03 +/- 0.58 and 4.20 +/- 0.58 h, respectively. The ratio of the areas under the concentration-time curves from 0 h to infinity for the p.o. and i.v. doses was 0.84, with a 90% confidence interval of 0.68 to 0.98; the mean absolute bioavailability was calculated to be 67% (range, 43 to 82%). From these data it appears that ciprofloxacin is adequately absorbed in patients with diabetic gastroparesis.
本研究的目的是评估环丙沙星在12例糖尿病胃轻瘫患者中的药代动力学特征。患者分别接受单次500毫克口服（p.o.）剂量和单次400毫克静脉注射（i.v.）剂量的环丙沙星，中间间隔1周的洗脱期。口服和静脉注射剂量的药代动力学参数（平均值±标准差）如下：0小时至无穷大的浓度-时间曲线下面积，分别为9.74±2.59和11.78±3.18微克·小时/毫升；血清中药物的最大浓度，分别为2.13±0.67和4.21±1.07微克/毫升；以及半衰期，分别为4.03±0.58和4.20±0.58小时。口服和静脉注射剂量从0小时至无穷大的浓度-时间曲线下面积之比为0.84，90%置信区间为0.68至0.98；计算得出的平均绝对生物利用度为67%（范围为43%至82%）。从这些数据来看，环丙沙星在糖尿病胃轻瘫患者中吸收良好。
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