Taha S A, Islam M W, Ageel A M
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Arch Int Pharmacodyn Ther. 1995 Mar-Apr;329(2):283-94.
The effect of ambrein, a major constituent of ambergris, was studied on the sexual behavior of male rats. The rats were administered ambrein in doses of 100 and 300 mg/kg body weight. Male sexual activities were assessed by recording the erectile responses (penile erection) and homosexual mountings in the absence of female. The copulatory studies were carried out by caging males with receptive females brought into estrus with subcutaneous injections of estradiol benzoate and progesterone. The copulatory pattern of treated male rats (mountings, intromissions, ejaculations and refractory period), the pendiculations (yawns/stretches) and orientation activities towards females, the environment and themselves, were recorded. Ambrein produced recurrent episodes of penile erection, a dose-dependent, vigorous and repetitive increase in intromissions and an increased anogenital investigatory behavior, identifying the drug used in the present study as a sexual stimulant. It is conceivable from the present results that the ambrein-modified masculine sexual behavior in male rats supports the folk use of this drug as an aphrodisiac.
对龙涎香的主要成分龙涎香醇对雄性大鼠性行为的影响进行了研究。给大鼠分别注射体重100毫克/千克和300毫克/千克剂量的龙涎香醇。通过记录无雌性情况下的勃起反应（阴茎勃起）和同性爬跨来评估雄性性行为。通过将雄性大鼠与经皮下注射苯甲酸雌二醇和孕酮诱导发情的可接受雌性大鼠关在同一笼中进行交配研究。记录经处理的雄性大鼠的交配模式（爬跨、插入、射精和不应期）、摆动动作（打哈欠/伸展）以及对雌性、环境和自身的定向活动。龙涎香醇引起阴茎反复勃起、插入次数呈剂量依赖性的剧烈且重复性增加以及肛门生殖器探究行为增加，表明本研究中使用的该药物为性兴奋剂。从目前的结果可以推测，龙涎香醇改变雄性大鼠的雄性性行为支持了这种药物作为壮阳药的民间用途。
