Taha S A, Ageel A M, Islam M W, Ginawi O T
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Pharmacol Res. 1995 May;31(5):299-303. doi: 10.1016/1043-6618(95)80035-2.
The effect of (-)-cathinone, caffeine and their combinations was studied on the sexual behaviour of male rats. Male sexual activities were assessed by recording the erectile responses (grooming of genitalis, yawning/stretching and homosexual mounting), in the absence of females. The copulatory behaviour was observed by caging males with receptive females brought into oestrus with s.c. injection of oestradiol benzoate and progesterone. The copulatory pattern of male rats (mounting, intromissions, ejaculations and refractory period) was recorded. The oral treatment of cathinone (5 mg kg-1 day-1), caffeine (50 mg kg-1 day-1) and their combinations for 15 days increased arousal (motivation) in male rats as evidenced by increased mounting performance and anogenital investigatory behaviour. However, erectile and ejaculatory responses, measured in the present study, showed no stimulant effect. It is conceivable from the present results that cathinone, the psychostimulant constituent of khat modified masculine pattern behaviour and caffeine also changed the effect of cathinone when administered concomitantly. However, our data provide no evidence that cathinone could be considered as an aphrodisiac.
研究了（-）-去甲伪麻黄碱、咖啡因及其组合对雄性大鼠性行为的影响。在无雌性大鼠的情况下，通过记录勃起反应（生殖器梳理、打哈欠/伸展和同性骑跨）来评估雄性性行为。将雄性大鼠与经皮下注射苯甲酸雌二醇和孕酮诱导发情的雌性大鼠同笼饲养，观察其交配行为。记录雄性大鼠的交配模式（骑跨、插入、射精和不应期）。口服去甲伪麻黄碱（5毫克/千克/天）、咖啡因（50毫克/千克/天）及其组合15天可提高雄性大鼠的性唤起（动机），表现为骑跨行为和肛门生殖器探究行为增加。然而，本研究中测量的勃起和射精反应未显示出刺激作用。从目前的结果可以推测，恰特草中的精神兴奋剂成分去甲伪麻黄碱改变了雄性模式行为，而咖啡因在与去甲伪麻黄碱同时给药时也改变了其作用。然而，我们的数据没有提供证据表明去甲伪麻黄碱可被视为一种壮阳药。
