Kallas M R, Patrício F R, Fagundes-Neto U
Disciplina de Anatomia Patológica da EPM, São Paulo, SP.
Arq Gastroenterol. 1995 Apr-Jun;32(2):91-8.
Enteropathogenic E.coli infection may cause different ranges of abnormalities in the small bowel villi, but there are no morphometric studies about it. Thirty specimens of small intestinal mucosa obtained from children having acute or persistent diarrhea by enteropathogenic E.coli were analysed and then compared to the specimens of the small intestinal biopsy of thirteen patients of the control group. We had the following target in this paper: evaluate the morphological changes of intestinal mucosa using linear morphometry and to verify the number of intra-epithelial lymphocytes/100 enterocytes; search the presence of Gram negative bacteria adhered to the small intestinal mucosa. Gram negative bacteria were present in three patients with acute diarrhea. The morphometric changes were more remarkable in the villosites which were shorter, in the enteropathogenic E.coli group. The total mucosa thickness as well as the villous height and the relation villous/crypt were significantly shorter in the enteropathogenic E.coli group when compared to the control Group. There were no differences between the two groups for the crypt length and for de number of intraepithelial lymphocytes/100 enterocytes.
肠道致病性大肠杆菌感染可能会导致小肠绒毛出现不同程度的异常，但目前尚无关于此的形态计量学研究。对30例因肠道致病性大肠杆菌导致急性或持续性腹泻的儿童的小肠黏膜标本进行了分析，并与13例对照组患者的小肠活检标本进行了比较。本文有以下目标：使用线性形态计量学评估肠黏膜的形态变化，并验证每100个肠上皮细胞中上皮内淋巴细胞的数量；寻找附着于小肠黏膜的革兰氏阴性菌。在3例急性腹泻患者中发现了革兰氏阴性菌。在肠道致病性大肠杆菌组中，较短绒毛部位的形态计量学变化更为显著。与对照组相比，肠道致病性大肠杆菌组的总黏膜厚度、绒毛高度以及绒毛/隐窝比值均显著缩短。两组在隐窝长度和每100个肠上皮细胞中上皮内淋巴细胞数量方面没有差异。
