Vogt B A, Kim Y, Jennette J C, Falk R J, Burke B A, Sinaiko A
Department of Pediatrics, University of Minnesota, Minneapolis.
J Pediatr. 1994 Jun;124(6):986-8. doi: 10.1016/s0022-3476(05)83199-3.
Propylthiouracil, which is commonly used in the treatment of hyperthyroidism, has been associated in adults with antineutrophil cytoplasmic autoantibody, a serologic marker of vasculitis. Severe renal disease has not been reported as a complication of therapy with this drug. We report severe antineutrophil cytoplasmic autoantibody-positive vasculitis in children receiving propylthiouracil, as well as rapidly progressive crescentic glomerulonephritis after administration of this drug.
