头颈部癌症中的干扰素及其他细胞因子。

Interferons and other cytokines in head and neck cancer.

作者信息

Hamasaki V K, Vokes E E

机构信息

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.

出版信息

Med Oncol. 1995 Mar;12(1):23-33. doi: 10.1007/BF01571405.

DOI:10.1007/BF01571405

PMID:8542243

Abstract

The use of cytokines in head and neck cancer is increasingly under investigation. Clinical trials have tested the interferons, interleukin-2 and other cytokines as single agents and in various combinations. The addition of interferon to the cisplatin and 5-fluorouracil (5-FU) regimens (with and without leucovorin) has been explored. A randomized international trial comparing cisplatin and 5-FU with cisplatin, 5-FU and interferon-alpha 2b is in progress.

摘要

细胞因子在头颈癌中的应用正越来越多地受到研究。临床试验已将干扰素、白细胞介素-2及其他细胞因子作为单一药物并以各种组合方式进行了测试。已探讨了在顺铂和5-氟尿嘧啶（5-FU）方案（加或不加亚叶酸）中添加干扰素的情况。一项比较顺铂和5-FU与顺铂、5-FU和干扰素-α2b的随机国际试验正在进行中。