Niezabitowski A, Limon J, Wasilewska A, Rys J, Lackowska B, Nedoszytko B
Department of Pathology, Oncology Centre, Cracow, Poland.
Gen Diagn Pathol. 1995 May;141(1):49-55.
A case of parachordoma in a 45-year-old female was described. Histologically, the recurrent lesion, in comparison with the primary tumor, demonstrated an increased cellular atypia and mitotic rate. The tumor cells expressed EMA, vimentin, S 100 protein, and also a trace desmin content was present. Electron microscopic study provided no characteristic features of the tumor type studied. Flow cytometric evaluation of the DNA demonstrated a diploid histogram with the relatively high S-phase. Cytogenetic analysis revealed normal karyotype, but a deviation from the diploid state in the form of aneuploid metaphases with non-clonal structural chromosomal aberrations was observed.
描述了一例45岁女性的副脊索瘤病例。组织学上，复发病变与原发肿瘤相比，细胞异型性增加，有丝分裂率升高。肿瘤细胞表达上皮膜抗原（EMA）、波形蛋白、S-100蛋白，且也存在微量的结蛋白。电镜研究未发现所研究肿瘤类型的特征性表现。DNA的流式细胞术评估显示为二倍体直方图，S期相对较高。细胞遗传学分析显示核型正常，但观察到非克隆性结构染色体畸变形式的非整倍体中期相，偏离了二倍体状态。
