The histogenesis of retinoblastoma. An electron-microscopic analysis of rosette.

The histogenesis of retinoblastoma has long been a constantly debatable problem since the last century. Rosettes of retinoblastoma have been studied by electron microscopy using 15 eyes as speciments. The evidences suggest that the rosette is at least composed of visual cells and glial (possibly Müller) cells, providing characteristics of the primitive retina. Therefore, it has been concluded that retinoblastoma does not arise from either of the developing neuronal or glial cells, but from the multipotential embryonic retinal cell which is capable of being differentiated into either of these two cellular systems.