Larsson J, Apelqvist J, Agardh C D, Stenström A
Department of Orthopaedics, University Hospital, Lund, Sweden.
Diabet Med. 1995 Sep;12(9):770-6. doi: 10.1111/j.1464-5491.1995.tb02078.x.
The purpose of this retrospective study was to evaluate the changes in diabetes-related lower extremity amputations following the implementation of a multidisciplinary programme for prevention and treatment of diabetic foot ulcers in a 0.2 million population with a 2.4% prevalence of diabetes. All diabetes-related primary amputations from toe to hip from 1 January 1982 to 31 December 1993 were included. In 294 diabetic patients, 387 primary major (above the ankle) or minor (through or below the ankle) amputations were performed, constituting 48% of all lower extremity amputations. The annual number of amputations at all levels decreased from 38 to 21, equalling a decrease of incidence from 19.1 to 9.4/100,000 inhabitants (p = 0.001). The incidence of major amputations decreased by 78% from 16/1 to 3.6/100,000 inhabitants (p < 0.001). The absolute number of amputations with a final level below the ankle showed no increase, but their proportion increased from 28 to 53% (p < 0.001) and the reamputation rate decreased from 36 to 22% (p < 0.05) between the first and last 3-year period. Thus, a substantial long-term decrease in the incidence of major amputations was seen as well as a decrease in the total incidence of amputations in diabetic patients. Seventy-one per cent of the amputations were precipitated by a foot ulcer. These findings indicate that a multidisciplinary approach plays an important role to reduce and maintain a low incidence of major amputations in diabetic patients.
本回顾性研究的目的是评估在一个糖尿病患病率为2.4%的20万人口中实施多学科糖尿病足溃疡预防和治疗项目后,糖尿病相关下肢截肢的变化情况。纳入了1982年1月1日至1993年12月31日期间所有从趾部到髋部的糖尿病相关原发性截肢病例。294例糖尿病患者共进行了387次原发性大截肢(踝关节以上)或小截肢(通过踝关节或踝关节以下),占所有下肢截肢的48%。各级截肢的年例数从38例降至21例,发病率从19.1/10万居民降至9.4/10万居民(p = 0.001)。大截肢的发病率从16/10万居民降至3.6/10万居民,下降了78%(p < 0.001)。最终截肢部位在踝关节以下的绝对例数没有增加,但其比例从28%增至53%(p < 0.001),且再次截肢率在第一个和最后一个3年期间从36%降至22%(p < 0.05)。因此,观察到糖尿病患者大截肢的发病率有显著的长期下降以及截肢总发病率的下降。71%的截肢是由足部溃疡引发的。这些发现表明,多学科方法在降低和维持糖尿病患者大截肢的低发病率方面发挥着重要作用。