Larramendy M, el-Rifai W, Saarinen U, Alitalo R, Luomahaara S, Knuutila S
Department of Medical Genetics, University of Helsinki, Finland.
Exp Hematol. 1995 Dec;23(14):1563-7.
We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.
我们在6例急性淋巴细胞白血病（ALL）患儿的骨髓穿刺物中寻找髓系细胞谱系中的克隆性染色体异常。该研究采用形态学、抗体、染色体（MAC）和原位杂交程序相结合的方法进行。在白血病细胞仅表达淋巴样抗原的患者中，我们在CD10和CD20/22阳性的淋巴样细胞中发现了染色体畸变。成熟的CD22 +和CD3 +淋巴细胞没有染色体畸变。在1例白血病细胞也表达髓系相关抗原的患者中，不仅在CD10 +和CD19 +母细胞中发现了克隆性染色体畸变，而且在糖蛋白A阳性的形态学上非白血病的成红细胞中也发现了克隆性染色体畸变。
