Bezrukov V F
Genetika. 1995 Oct;31(10):1438-44.
Peculiarities of interdependent variation of monogenic and polygenic traits were analyzed using a one-locus diallelic model of a monogenic, dominantly inherited trait. The possibility of determining the mean genotypic value of the trait (m) and also the additive (a) and nonadditive (d) effects of the interaction between alleles of a monogenic trait on a quantitative trait is considered. It is shown that a and d can differ from zero even if the mean values in the groups with dominant and recessive phenotypes are equal. Equations are presented that allow the direct use of data obtained in population studies for determining m, a, and d, as well as corresponding standard errors under the conditions of codominance and dominance of the monogenic trait. Another group of equations allows determination of the sample size necessary for calculating m, a, and d. The problem concerning the ambiguity of m, a, and d values calculated using the proposed equations is discussed. This ambiguity depends on the fact that identification of genotypes in the case of a dominantly inherited monogenic trait is impossible.
使用单基因显性遗传性状的单基因座双等位基因模型，分析了单基因和多基因性状相互依存变异的特点。考虑了确定性状平均基因型值（m）以及单基因性状等位基因间相互作用对数量性状的加性（a）和非加性（d）效应的可能性。结果表明，即使显性和隐性表型组的平均值相等，a和d也可能不为零。给出了一些方程，可直接利用群体研究中获得的数据，在单基因性状共显性和显性条件下确定m、a和d，以及相应的标准误差。另一组方程可确定计算m、a和d所需的样本量。讨论了使用所提出的方程计算m、a和d值时的模糊性问题。这种模糊性取决于这样一个事实，即在显性遗传的单基因性状情况下，基因型的鉴定是不可能的。
