Halbach S
Institute of Toxicology, GSF Research Center for Environment and Health, Oberschleissheim, Germany.
Int Arch Occup Environ Health. 1995;67(5):295-300. doi: 10.1007/BF00385643.
Amalgam fillings constitute, after food, the main source of exposure to mercury for the general population. An evaluation of potential health risks has to be based on the dose of mercury released from the fillings. This dose is estimated by a new procedure of mercury speciation which elutes the released elemental and inorganic mercury with solvents of different polarity (paraffin and saline). In vitro tests with spherical amalgam pellets have shown that mercury release into the solvents is linearily correlated to time and amalgam surface area. Doses estimated in volunteers by this method average 4.5 micrograms/day (range 0.3-13.9), as compared to a dose of 3.4 micrograms/day (range 0.1-11.8) measured conventionally in the oral air. The aforementioned dose, combined with the nearly equal mercury uptake from food, is below the acceptable daily intake of 40 micrograms for all forms of mercury.
除食物外，汞合金填充物是普通人群接触汞的主要来源。对潜在健康风险的评估必须基于填充物释放的汞剂量。该剂量通过一种新的汞形态分析程序估算，该程序用不同极性的溶剂（石蜡和盐水）洗脱释放出的元素汞和无机汞。对球形汞合金颗粒进行的体外试验表明，汞向溶剂中的释放与时间和汞合金表面积呈线性相关。通过这种方法估算的志愿者体内汞剂量平均为4.5微克/天（范围为0.3 - 13.9），而传统方法在口腔空气中测得的剂量为3.4微克/天（范围为0.1 - 11.8）。上述剂量加上从食物中摄取的几乎等量的汞，低于所有汞形态40微克的每日可接受摄入量。
