Begerow J, Zander D, Freier I, Dunemann L
Medizinisches Institut für Umwelthygiene, Düsseldorf, Germany.
Int Arch Occup Environ Health. 1994;66(3):209-12. doi: 10.1007/BF00380782.
The long-term urinary mercury excretion was determined in 17 28- to 55-year-old persons before and at varying times (up to 14 months) after removal of all (4-24) dental amalgam fillings. Before removal the urinary mercury excretion correlated with the number of amalgam fillings. In the immediate post-removal phase (up to 6 days after removal) a mean increase of 30% was observed. Within 12 months the geometric mean of the mercury excretion was reduced by a factor of 5 from 1.44 micrograms/g (range: 0.57-4.38 micrograms/g) to 0.36 microgram/g (range: 0.13-0.88 microgram/g). After cessation of exposure to dental amalgam the mean half-life was 95 days. These results show that the release of mercury from dental amalgam contributes predominantly to the mercury exposure of non-occupationally exposed persons. The exposure from amalgam fillings thus exceeds the exposure from food, air and beverages. Within 12 months after removal of all amalgam fillings the participants showed substantially lower urinary mercury levels which were comparable to those found in subjects who have never had dental amalgam fillings. A relationship between the urinary mercury excretion and adverse effects was not found. Differences in the frequency of effects between the pre- and the post-removal phase were not observed.
对17名28至55岁的人在拔除所有（4至24颗）牙科汞合金填充物之前以及拔除后不同时间（最长14个月）的长期尿汞排泄情况进行了测定。在拔除之前，尿汞排泄与汞合金填充物的数量相关。在拔除后的即刻阶段（拔除后至多6天），观察到平均增加了30%。在12个月内，汞排泄的几何平均值从1.44微克/克（范围：0.57至4.38微克/克）降至0.36微克/克（范围：0.13至0.88微克/克），降低了5倍。停止接触牙科汞合金后，平均半衰期为95天。这些结果表明，牙科汞合金释放的汞是未从事职业接触的人群汞暴露的主要来源。因此，汞合金填充物造成的暴露超过了食物、空气和饮料造成的暴露。在拔除所有汞合金填充物后的12个月内，参与者的尿汞水平大幅降低，与从未有过牙科汞合金填充物的受试者的水平相当。未发现尿汞排泄与不良反应之间的关系。未观察到拔除前后阶段不良反应发生频率的差异。
