Glass L F, Fenske N A, Jaroszeski M, Perrott R, Harvey D T, Reintgen D S, Heller R
Department of Internal Medicine, University of South Florida College of Medicine, Tampa, USA.
J Am Acad Dermatol. 1996 Jan;34(1):82-6. doi: 10.1016/s0190-9622(96)90838-5.
A new technique, electroporation, enhances the antitumor effects of a variety of chemotherapeutic agents. When used in combination with conventional chemotherapy, the procedure is termed electrochemotherapy. Exposure of cancerous tissues to pulses of electricity during electrochemotherapy appears to increase cell membrane permeability and thus intracellular access to cytotoxic drugs. Electrochemotherapy has been shown to have potent antitumor activity in a variety of in vitro studies, animal tumor models, as well as in clinical trials with squamous cell carcinomas of the head and neck.
The purpose of the study was to determine the effects of bleomycin-mediated electrochemotherapy on several basal cell carcinomas (BCCs) in two patients with nevoid BCC syndrome.
Electrical pulses were delivered to tumor nodules by means of caliper electrodes after systemic doses of bleomycin were administered. Vital signs were closely monitored during application of the electrical pulses.
Partial responses were observed in tumors from both of the patients treated with electrochemotherapy; three partial responses were observed in one patient, and one partial response was observed in the other patient. Complete responses were seen in two lesions. Only minimal local or systemic side effects were noted in response to the therapy.
To our knowledge, this is the first study that documents the effects of bleomycin-mediated electrochemotherapy on BCC. Studies are ongoing with intralesional bleomycin during electrochemotherapy to see whether additional antitumour effects can be produced in patients with BCC by this route of administration.
一种新技术——电穿孔，可增强多种化疗药物的抗肿瘤效果。当与传统化疗联合使用时，该过程被称为电化学疗法。在电化学疗法中，癌组织暴露于电脉冲下似乎会增加细胞膜通透性，从而使细胞内更易摄取细胞毒性药物。在各种体外研究、动物肿瘤模型以及头颈部鳞状细胞癌的临床试验中，电化学疗法已显示出强大的抗肿瘤活性。
本研究的目的是确定博来霉素介导的电化学疗法对两名痣样基底细胞癌综合征患者的几种基底细胞癌（BCC）的影响。
在给予全身剂量的博来霉素后，通过卡尺电极向肿瘤结节施加电脉冲。在施加电脉冲期间密切监测生命体征。
接受电化学疗法治疗的两名患者的肿瘤均观察到部分缓解；一名患者观察到3次部分缓解，另一名患者观察到1次部分缓解。在两个病灶中观察到完全缓解。治疗后仅观察到轻微的局部或全身副作用。
据我们所知，这是第一项记录博来霉素介导的电化学疗法对BCC影响的研究。目前正在进行电化学疗法期间瘤内注射博来霉素的研究，以观察通过这种给药途径是否能在BCC患者中产生额外的抗肿瘤效果。
