20例基底细胞癌患者采用瘤内注射博来霉素介导的电化学疗法。
Intralesional bleomycin-mediated electrochemotherapy in 20 patients with basal cell carcinoma.
作者信息
Glass L F, Jaroszeski M, Gilbert R, Reintgen D S, Heller R
机构信息
Department of Dermatology, University of South Florida College of Medicine, Tampa 33612, USA.
出版信息
J Am Acad Dermatol. 1997 Oct;37(4):596-9. doi: 10.1016/s0190-9622(97)70178-6.
BACKGROUND
A new anticancer therapy, electrochemotherapy (ECT), has been introduced that entails exposing cancerous tissues to short pulses of electricity during chemotherapy. This enhances cell membrane permeability and has been shown to have potent antitumor effects in vitro in animal models and in several clinical trials, including nevoid basal cell carcinoma (BCC).
OBJECTIVE
We report the effects of ECT on 20 patients with primary BCC.
METHODS
Electrical pulses were delivered to 54 tumors after administration of intralesional bleomycin sulfate.
RESULTS
Complete responses were observed in 53 (98%), and in the majority of these (94%) after a single treatment. No recurrences have been recorded with a mean of 18 months of observation.
CONCLUSION
Although these are preliminary results, ECT appears to be an effective alternative to surgical excision for the treatment of primary BCC.
背景
一种新的抗癌疗法——电化学疗法（ECT）已被引入，该疗法需要在化疗期间将癌组织暴露于短脉冲电流中。这增强了细胞膜通透性，并且在动物模型的体外实验以及包括痣样基底细胞癌（BCC）在内的多项临床试验中已显示出强大的抗肿瘤作用。
目的
我们报告ECT对20例原发性BCC患者的疗效。
方法
在病灶内注射硫酸博来霉素后，对54个肿瘤施加电脉冲。
结果
观察到53例（98%）完全缓解，其中大多数（94%）在单次治疗后实现完全缓解。平均18个月的观察期内未记录到复发情况。
结论
尽管这些是初步结果，但ECT似乎是治疗原发性BCC的一种有效的手术切除替代方法。
Zotero 插件