Dhainaut J F, Geschwind H, Gourdier M, Magnier S, Laurent D
Arch Mal Coeur Vaiss. 1978 Dec;71(12):1347-55.
The charges of left ventricular function provoked by coupled electrical stimulation were studied in 17 patients with severe chronic aortic incompetence and 9 controls. These results were compared with those obtained after isolated extrasystole in 24 cases of aortic incompetence and 10 controls, and during paired electrical stimulation in 12 cases of aortic incompetence. Left ventricular function increased uniformly after post-extrasystolic potentiation whatever the mode of stimulation. The preload did not change significantly, the increased ventricular function being mainly due to increased contractility. Coupled electrical stimulation mobilised the greatest contractility reserve (ejection fraction : +32 % in controls and +37 % in aortic incompetence and averaged circumferentiel fibre shortening +55 % in controls and +47 % in aortic incompetence). The contractility reserve is inversely proportional to the initial ejection fraction except when its value is less than 35 %. The myocardial response then becomes variable so that left ventricles with probable irreversible hypocontractility may be distinguished from those whose ventricular funciton would improve after surgical correction.
对17例重度慢性主动脉瓣关闭不全患者和9名对照者进行了耦合电刺激引发的左心室功能变化研究。将这些结果与24例主动脉瓣关闭不全患者和10名对照者在单发期外收缩后、以及12例主动脉瓣关闭不全患者在成对电刺激期间所获得的结果进行比较。无论刺激方式如何，期外收缩后增强后左心室功能均一致增加。前负荷无显著变化，心室功能增加主要归因于收缩力增强。耦合电刺激调动了最大的收缩力储备（射血分数：对照者增加32%，主动脉瓣关闭不全患者增加37%；平均圆周纤维缩短率：对照者增加55%，主动脉瓣关闭不全患者增加47%）。收缩力储备与初始射血分数成反比，但其值小于35%时除外。此时心肌反应变得多变，因此可将可能存在不可逆性收缩功能减退的左心室与手术矫正后心室功能会改善的左心室区分开来。
