Asahina A, Hosoi J, Grabbe S, Granstein R D
Department of Dermatology and Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, USA.
J Allergy Clin Immunol. 1995 Dec;96(6 Pt 2):1178-82. doi: 10.1016/s0091-6749(95)70203-2.
Many if not most epidermal Langerhans cells appeared to be closely associated anatomically with calcitonin gene-related peptide (CGRP)-containing nerves as determined by confocal laser scanning microscopy. Furthermore, a small proportion of Langerhans cells had immunoreactive CGRP at or near their cell surfaces, suggesting that nerves are capable of depositing CGRP at or near Langerhans cells. CGRP inhibited Langerhans cell antigen-presenting capability for elicitation of delayed-type hypersensitivity in immunized mice to present alloantigens in the mixed epidermal cell-lymphocyte reaction and to present a protein antigen to a responsive hybridoma. As a whole, these data suggest the possibility that products of nerves within the epidermis might serve to regulate Langerhans cell function. The apparent apposition of epidermal nerves with Langerhans cells suggests a possible locus of interaction between the nervous system and the immune system within the skin.
通过共聚焦激光扫描显微镜观察发现，许多（即便不是大多数）表皮朗格汉斯细胞在解剖学上似乎与含降钙素基因相关肽（CGRP）的神经紧密相连。此外，一小部分朗格汉斯细胞在其细胞表面或附近有免疫反应性CGRP，这表明神经能够在朗格汉斯细胞表面或附近沉积CGRP。CGRP抑制了朗格汉斯细胞在免疫小鼠中引发迟发型超敏反应的抗原呈递能力，在混合表皮细胞-淋巴细胞反应中呈递同种异体抗原，并将蛋白质抗原呈递给反应性杂交瘤。总体而言，这些数据表明表皮内神经产物可能调节朗格汉斯细胞功能的可能性。表皮神经与朗格汉斯细胞的明显并列提示了皮肤内神经系统与免疫系统之间可能的相互作用位点。
